AKT1 and diabetes mellitus: The concentration of glycogen was also significantly decreased inthe skeletal muscle of diabetes induced rats when compared with control rats which is may be due to impairment in the process of glycogenesis as a result of diminished Akt phosphorylation at Thr308 which is essential event in the activation of glycogensynthase [33] Upon treatment with β- Caryophyllene the glycogen content was restored to the normal level.