ERVW-1 and HIV infectious disease: The main role of Immunoglobulin λ chain is antigen binding in human infection and has shown biased properties.A significant bias toward use of the λ light chain in the anti-HIV Env response was observed in individuals with acute HIV infection, those with chronic HIV infection, HIV-negative vaccines, and HIV clades (clade B, clade G, and CRF02_AG).The biased λ chain is associated with enhanced binding of anti-HIV Env glycoprotein antibodies in HIV patients and an effector molecule in humoral response [22].