PLAU and neoplasm: [8] EMMPRIN is associated with many proteins that are involved in different signalling pathways, includingintegrins, caveolin-1 (Cav-1), tenascin (TN)-C, urokinase-type plasminogen activator (uPA), matrix metalloproteinases, ErbB, MAPK cascade proteins, monocarboxylate transporters (MCT), and cyclophilins (Cyp)[9] EMMPRIN has the ability to increase angiogenesisin the tumour microenvironment by inducing vascular endothelial growth factors in tumour and stromal cells.