[10] The urge for survival that causes metabolic alteration in tumour cells is a hallmark of carcinogenesis.EMMPRIN creates complexes on the membrane and regulates the expression and activity of monocarboxylate transporters-1 (MCT-1) and MCT-4 to transfer the lactic acid generated by anaerobic glycolysis. Here, SLC16A1 is linked to neoplasm.