In particular, nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing 1 (NLRP1) and 3 (NLRP3) inflammasomes, are overexpressed in the brain following ischemia (Fann et al., 2018; Jiang et al., 2020; Qiu et al., 2022). Here, NLRP3 is linked to ischemia.