NLRP3 and stroke disorder: This finding corroborates the recent literature suggesting the importance of neuronal inflammasome activation in stroke pathophysiology, including Gong et al.’s study, which indicated that the NLRP3 inflammasome expressed by microglia initially was followed by microvascular endothelial cells and neurons, but principally in neurons 24-h after cerebral I/R (Gong et al., 2018).