SERPINA1 and Cirrhosis: Cirrhosis is a life-threatening chronic and progressive liver disease that develops primarily as a consequence of chronic hepatitis B or hepatitis C virus infections, or alcohol-related or non-alcoholic steatohepatitis, with other rarer causes including alpha-1-antitrypsin deficiency, haemochromatosis, primary sclerosis cholangitis, Wilson’s disease, etc.1,2 Being the 11th leading cause of death in the world, cirrhosis accounted for 2.2% of total deaths in 20163 and 2.4% of total deaths in 2017,4 with an annually increasing mortality rate.4