Both CXCL8 (IL-8) and CXCL1 have been shown to be highly elevated in the serum of patients with cirrhosis, which is even more pronounced in patients with ACLF.[44], [45], [46] This might initially preserve chemotaxis due to ligand excess or may also cause the homologous desensitisation of their receptors on neutrophils due to the prolonged excess of ligands, their downregulation and the subsequent decrease in neutrophil migration. The gene discussed is CXCL8; the disease is Cirrhosis.