Interestingly, the impairment in migration in the presence of fMLF is more pronounced in patients with acute decompensation and ACLF than in patients with compensated cirrhosis or healthy volunteers, which is less evident or absent (though with a tendency towards a decrease) when CXC motif ligand (CXCL)8 or CXCL1 is used as a chemoattractant. The gene discussed is CXCL8; the disease is Cirrhosis.