The in vivo study on mice fed with high fat diet showed a significant correlation between sICAM-1 with body weight and visceral fat or central obesity due to the expression ICAM-1 mRNA on the adipose tissue, which is higher on male mice than female mice, followed by the increment of IL-6 and monocyte chemoattractant protein-1 (MCP-1) as the consequences of atherogenic lipid (LDL-c, cholesterol, and triglyceride) in the diet [77]. Here, IL6 is linked to Abdominal obesity.