Path analysis to analyse the effect of MetS components (waist circumference, fasting blood glucose, triglycerides, HDL-c, and systole and diastole blood pressure) on ICAM-1 showed that diastole-BP and triglyceride levels had a direct effect on ICAM-1 in boys, as summarized in Figure 1, while insulin and adiponectin levels did not show their effect on ICAM-1 or VCAM-1 directly or indirectly. The gene discussed is VCAM1; the disease is metabolic syndrome.