TNF and obesity due to melanocortin 4 receptor deficiency: Adiponectin is accumulated in the vasculature, and it reduced on obesity due to suppression by TNF-α and lead to adiponectin-deficiency, which stimulate the significant increases of vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) or known as CD54 in aortic intima [6].