It has been proposed that adiponectin acts to prevent the vascular dysfunction due to obesity and diabetes by improving insulin sensitivity and metabolic profiles to reduce the risk factors for cardiovascular disease and protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells, and macrophages [1]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.