An in vivo study showed that insulin concentration (10−9–10−7 mol/L) induced VCAM-1 expression and markedly increased TNF-α via NF-kB activation and IkB-α accumulation [64], so we suspect that hyperinsulinemia stimulates the expression of VCAM-1, not the blood pressure. The gene discussed is VCAM1; the disease is Hyperinsulinemia.