In the latter study the selective removal of senescent cells in INK-ATTAC mice (inducible whole-body transgenic mouse model that allows specific deletion of p16Ink4a expressing cells after administration of a B/B homodimerizer that promotes activation of caspase 8 only in p16Ink4a positive cells) (51) reduced hepatic steatosis in aging, obese, and diabetic mice. The gene discussed is CDKN2A; the disease is fatty liver disease.