When C6 glioma cells were virally transfected to express GRP78 and cultured with the ER stress-inducer tunicamycin, cells expressing GRP78 had significantly lower levels of apoptosis compared to control C6 cells, demonstrating the cytoprotective effect of GRP78 (Suyama et al., 2011). The gene discussed is HSPA5; the disease is glioma.