GLP-1R activation in the brain exerts neurotrophic and neuroprotective effects, demonstrating protective effects against various neurodegenerative conditions such as ischemia, stroke, Alzheimer's disease, Parkinson's disease, and brain trauma (Fang et al., 2020) (Bader et al., 2019) (Rachmany et al., 2013). The gene discussed is GLP1R; the disease is Parkinson disease.