GLP-1R activation in the brain exerts neurotrophic and neuroprotective effects, demonstrating protective effects against various neurodegenerative conditions such as ischemia, stroke, Alzheimer's disease, Parkinson's disease, and brain trauma (Fang et al., 2020) (Bader et al., 2019) (Rachmany et al., 2013). Here, GLP1R is linked to ischemia.