However, other potential explanations for the protective effects including unique effects on the APOE genotype-dependent transcriptomic signature (Taubes et al., 2021), potent diuretic effects, and off-target metabolic, cardiorespiratory, and hormonal alterations that may be indirectly linked to reducing the risk of AD are also a possibility (Brater, 1991; Puskarjov et al., 2014). Here, APOE is linked to Alzheimer disease.