The Rbfox family proteins are highly expressed in brain neurons and regulate the splicing of neuronal transcript.[18] Downregulation of the Rbfox family members is frequent in older individuals and contributes to loss of synaptic function in Alzheimer's disease.[18] Recent evidences have supported an oncogenic role of Rbfox2 in cancer.[26] For example, Rbfox2 mediates TGF‐β‐induced EMT and invasiveness of tumor cells.[27] However, the downstream splicing events of Rbfox2 that mediate tumor initiation and EMT remain largely elusive. The gene discussed is TGFB1; the disease is early-onset autosomal dominant Alzheimer disease.