Knockout of FBXO7 in mice is embryonically lethal as neurons die prematurely.[6] Mutation of FBXO7, which destabilizes FBXO7 protein,[7] is frequent in Parkinson's disease (PD) and is the main cause of early‐onset PD.[8] Recent studies support that mutation or deficiency of FBXO7 will lead to mitochondrial dysfunction and blockage of mitophagy, which contribute to the pathogenesis of PD.[9] There are only a few reports of FBXO7 in cancer, and the results are often contradictory. This evidence concerns the gene FBXO7 and cancer.