There are challenges to be overcome in the translational relevance of ALDH2: 1) ALDH2 has mainly protective roles in the heart and the cardiac vasculature, and we propose a tissue‐specific strategy of ALDH2 inhibition to improve risk management of cardiovascular disease.[29, 52, 53] Patients with a high risk of developing AAA as opposed to ischemic heart disease (IHD) may likely benefit more from ALDH2 inhibition. The gene discussed is ALDH2; the disease is myocardial ischemia.