It is noteworthy that pretreatment with AAV1‐ELK3 abolished the accelerated effect of ALDH2 in aortic dilation (Figure 5K,L; Figure S13D, Supporting Information), degradation of elastic fibers and the degree of collagen deposition (Figure S13E,F, Supporting Information) after Ang II infusion, indicating ELK3 acted as the ALDH2 downstream to restrict endothelial dysfunction in early progression of AAA. This evidence concerns the gene AGT and triple-A syndrome.