AAA was established by high fat feeding plus Ang II infusion (Figure S5B, Supporting Information), which is considered to recapitulate the major features of human AAA.[35, 36] Strong GFP fluorescence signals in ECs confirmed the successful viral delivery 4 weeks after AAV1‐ICAM2 injection into ApoE−/− mice (Figure S5C, Supporting Information). This evidence concerns the gene APOE and triple-A syndrome.