APP/IR‐dKI mice exhibited typical features of insulin resistance in the insulin tolerance test (ITT) (p = 0.0174 at 10 min, p = 0.0047 at 30 min, and p = 0.0033 at 60 min; Figure 1a) and glucose tolerance test (GTT) (p = 0.182 at 0 min, p = 0.612 at 15 min, p = 0.0350 at 30 min, p = 0.0281 at 60 min, and p = 0.293 at 120 min; Figure 1b) and higher serum insulin levels compared with APP‐KI mice (p = 0.0007; Figure 1c). The gene discussed is INS; the disease is Insulin resistance.