IGFBP3 and coronary artery disorder: The identified cluster in Figure 1B (CRP, SAA, sICAM1, MMP9, IGFBP3, sgp130, and sVCAM1 (r = .97 [.93–1.00]) indicates that correlated changes in these immunologically active proteins could contribute synergistically to the pathogenesis of CAD due to a common upstream regulator.