In Hepatitis B-related HCC, the outcomes demonstrated that FANCD2 was positively correlated with the expression of immune checkpoints, including CD274 (P = 0.008; P Spearman, 0.22), HAVCR2 (P = 7.54e−07; P Spearman, 0.40), LAG3 (P = 5.16e−07; P Spearman, 0.41), PDCD1 (P = 1.16e-05; P Spearman, 0.36), and TIGIT (P = 1.63e−05; P Spearman, 0.35) in Fig. 7. Here, TIGIT is linked to hepatitis B virus infection.