In Hepatitis B-related HCC, high FANCD2 expression had a poor overall survival (OS, Log-rank P, 0.000193; HR, 2.689; 95% Cl, 1.599–4.524), progression-free survival (PFS, Log-rank P, 0.000439; HR, 2.284; 95% Cl, 1.441–3.619), disease-free survival (DFS, Log-rank P, 0.00107; HR, 2.391; 95% Cl, 1.418–4.029) and disease-specific survival (DSS, Log-rank P, 0.000833; HR, 3.092; 95% Cl, 1.595–5.996) in TCGA database (Fig. 3). The gene discussed is FANCD2; the disease is hepatocellular carcinoma.