A significant difference in the diagnostic signature between the nephrotic subjects (DNgroup) (median: 1.33, IQR: 0.15~4.56) and non-nephrotic subjects (N + DMgroup) (median: -2.07, IQR: -3.02~-0.57, P < 0.001).(Fig. 7D) Therefore, the lncRNA GAS5/miR⁃21 diagnostic signature could provide a good distinction between diabetic nephropathy patients and non-nephropathy patients with or without diabetes. This evidence concerns the gene GAS5 and diabetic kidney disease.