Of the 47 genes altered in COPD cases, the top ten with the greatest fold changes were AHRR, CYP1B1, CYP4F2, CYP4F3, GAD1, LOC284825, MATN2, MCL1, MEP1A, and TPRXL (Fig. 4B). The gene discussed is MATN2; the disease is chronic obstructive pulmonary disease.