Of the 47 genes altered in COPD cases, the top ten with the greatest fold changes were AHRR, CYP1B1, CYP4F2, CYP4F3, GAD1, LOC284825, MATN2, MCL1, MEP1A, and TPRXL (Fig. 4B). Here, TPRXL is linked to chronic obstructive pulmonary disease.