In addition, a recent study by feeding nitrate-added drinking water to mice with chronic ischemia in the hind limbs for 2 weeks found increased mobilization of CD34(+)/Flk-1(+) cells and migration of bone-marrow-derived (BMD)CD31(+)/CD45(−) cells to the site of ischemia, correlating with enhanced revascularization [166, 167]. This evidence concerns the gene PECAM1 and ischemia.