Bone bridging protein (OPN), a molecule associated with tissue neutrophil infiltration, myeloperoxidase (MPO) and resistin are associated with neutrophil activation and are considered alternative markers of neutrophil recruitment and oxidative burst, and high levels of OPN and MPO at admission in cardiac arrest patients were found to be independent predictors of abnormal EEG changes in the subsequent 48 h in a related study, predicting early risk of secondary neurological injury and was associated with a poor neurological prognosis at 6 months. The gene discussed is SPP1; the disease is cardiac arrest.