PTK2 and neoplasm: Coincidently, using the human epidermoid carcinoma HEp3 cells that were passaged 120 to 170 times in chicken embryos as a dormancy model, a previous study found that genetic inhibition of FAK could mimic the tumor dormancy induced by the specific microenvironment, in which FAK was activated by the urokinase plasminogen activator receptor (uPAR) and mediating the expression of ERK [91].