We further conducted multivariate Cox regression analysis and depicted as a forest boxplot in Fig. 3H, which demonstrated that tumor status (HR = 1.808, p = 0.004) and AP4M1(HR = 1.641, p = 0.014) were independent predictors of HCCprognosis, implying a crucial role of AP4M1 in HCC. Here, AP4M1 is linked to neoplasm.