KEGG enrichment results suggested that AP4M1 and co-expressed genes were mainly involved in the Ribosome, Spliceosome, RNA transport, Shigellosis, Ribosome biogenesis in eukaryotes, Synaptic vesicle cycle, Proteasome, Cell cycle, Pyrimidine metabolism, Mismatch repair (Fig. 7D). The gene discussed is AP4M1; the disease is shigellosis.