In this meta-analysis, seven studies on sPD-L1 involving 554 patients with NSCLC, six studies on PD-L1 in CTCs involving 247 patients with NSCLC, and two studies on exoPD-L1 involving 171 patients with NSCLC were included to investigate the prognostic effect of these blood markers in patients with NSCLC undergoing ICI therapy. This evidence concerns the gene CD274 and non-small cell lung carcinoma.