In particular, sodium-glucose cotransporter 2 (SLGT2) inhibitors, the most viable oral anti-diabetic drugs to maintain optimal glycemic control, may be beneficial to cognitive improving in older adults with frailty associated with T2DM [41], probably by attenuated mitochondrial Ca2+ overload and reduced mitochondrial oxidative stress in endothelial cells [42]. Here, SLC5A2 is linked to type 2 diabetes mellitus.