CASP8 and cancer: Using the key words “gallbladder carcinoma” and “cancer”, we identified the top 10 genes, namely BRCA1, CHEK2, RB1, CASP8, PTGS2, CD44, KRT19, CDK1, PVT1, and MXRA5 were most correlated with the disease, in which PVT1 encoded lncRNA (Table 2).