VEGFA and neoplasm: Hence, 131 GBC-related DE-miRNAs were obtained by taking the intersection of hub miRNAs related to tumor, hub miRNAs related to survival, up-regulated miRNAs, and down-regulated miRNAs (Fig. 4A, Table S2) The results from the miRNA enrichment analysis showed that those dysregulated miRNAs were mainly associated with VEGF signaling pathway and positive regulation of endothelial cell proliferation (Fig. 4B, Fig. S1 and Table S3), which were considered as important for GBC progression.