The expression values of HOXB8, INHBB, and KLK10 were significantly upregulated in tumor tissues, while ZFP36 were highly expressed in normal tissues, which were validated in paired tumor and normal tissues (Fig. 7k, S15A-D: TCGA COAD, GSE32323, GSE44076, GSE89076, and GSE113513). The gene discussed is ZFP36; the disease is neoplasm.