While a previous study [179] has shown that using LY294002 as a PI3K/AKT inhibitor can activate FOXO3a in the nucleus, a recent study [137] has shown using NVP-BEZ235 (as another PI3K inhibitor) was not enough to induce its nuclear localization in GBM cells. The gene discussed is AKT1; the disease is glioblastoma.