AKT1 and central nervous system cancer: Studies have reported that FOXO3 can control cell cycle via increasing transcriptional activity of two important pro-apoptotic genes including BIM [183, 190, 191, 209, 215–217]and p27 [184, 187, 188, 218–220] in gliomas, emphasizing the tumor suppressive impact of Akt/FOXO3a/BIM axis [183, 190, 191].