Various upstream regulators of Akt such as CLK2 (oncogene) [187, 188], IGF1 (dual role) [189], SPHK1(oncogene) [190], CHAF1A (oncogene) [191], and importantly FOXM1B (oncogene) [192] was found to exert their function by affecting Akt/FOXO3 axis in gliomas. The gene discussed is FOXO3; the disease is glioma.