In contrast, Lu et al. have shown that miR-370 as a downregulated tumor suppressor miRNA by targeting 3′ UTR of β-catenin mRNA, suppresses its expression in astrocytoma and GBM cells and subsequently promoting FOXO3a nuclear accumulation, suppressing cancer cell proliferation [214]. This evidence concerns the gene FOXO3 and astrocytoma (excluding glioblastoma).