It was showed the top five GSEA enrichment gene sets involved in inflammation, CD5 cells, natural killer cells and B lymphocyte in Fig. 2E. Collectively, These evidences indicated that 17 intersection genes mentioned may play an important role in the pathogenesis of CTEPH by participating in the regulation of immune cells and cytokines. This evidence concerns the gene CD5 and chronic thromboembolic pulmonary hypertension.