SIRT1 and Hyperglycemia: The natural metabolite of triiodothyronine (T3) in the deiodination pathway, 3,5-diiodothyronine (T2), prevented a significant decrease in renal SIRT1 protein expression and activity in diabetic rats, thereby protecting the kidney [24].Third, hyperglycemia.Datas suggest that T3 could prevent progressive kidney injury by improving insulin signaling [25–27].