AD has a complex and multifactorial pathophysiology (Gavrilova and Alvarez 2021), where the accumulation of amyloid-β cerebral plaques (Aβ) and neurofibrillary tangles (NFTs) of abnormally insoluble Tau (an axonal protein) are common pathologic features (Knorz and Quante 2022). The gene discussed is MAPT; the disease is Alzheimer disease.