As shown in Fig. S2, of the 23 MMPs evaluated (MMP18 was not detected in GSE62452), 12 genes were significantly up-regulated in pancreatic cancer tissues (MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13, MMP14, and MMP28), while seven genes were significantly down-regulated (MMP17, MMP20, MMP21, MMP23B, MMP24, MMP25, and MMP26). This evidence concerns the gene MMP23B and familial pancreatic carcinoma.