BRCA1 and cancer: The proportion of germline SV mutations in BRCA1 and BRCA2 was markedly elevated in OC (BRCA1, 3.4%; BRCA2, 1.7%; Fig. 2d) and PC (BRCA2, 2.2%; Fig. 2e) compared to other cancers, as was the proportion of germline SV mutations in the HR genes RAD51C and RAD51D in OC (Supplementary Fig. 2).