MSH6 and neoplasm: As expected, TP53 (Fig. 1f, Table 3) was the most frequently altered DDR gene across all five tumour types (68.1%), followed by ARID1A (7.2%), ATM (4.6%), SMARCA4 (3.9%), MDM2 (3%), BRCA2 (3.3%), BRCA1 (2.4%), MUTYH (1.8%), CHEK2 (1.7%), ATR (1.2%), and MSH6 (1.1%).