Across the tumour types analysed, SV mutations of somatic origin were predominant in TP53 (Fig. 2f; BC, 44.4%; CRC, 58.4%; NSCLC, 53.9%; OC, 62.2%; PC, 26.9%), the DNA damage sensor gene ATM (BC, 3.6%; CRC, 3.3%; NSCLC, 3.0%; OC, 1.1%; PC, 2.6%), SWI/SNF chromatin remodelling genes ARID1A (BC, 17.4%; CRC, 5.1%; NSCLC, 5.1%; OC, 5.1%; PC, 1.4%), SMARCA4 (BC, 2.0%; CRC, 0.8%; NSCLC, 4.9%; OC, 0.4%; PC, 0.2%) and in the mismatch repair gene MSH3 (BC, 0.3%; CRC, 1.6%; NSCLC, 0.4%; OC, 0.2%; PC, 0.6%; Supplementary Fig. 2). The gene discussed is TP53; the disease is pachyonychia congenita.