TP53 mutations were associated with PD-L1-high status in BC (OR 2.48, p = 5.48E–26), NSCLC (OR = 1.56, p = 7.2E–58) and OC (OR 1.65, p = 4.66E–13) but not in CRC or PC. This evidence concerns the gene TP53 and pachyonychia congenita.