In tumours that were both TMB-high and PD-L1-high, a significant enrichment of GAs in individual DDR genes was observed in CRC (ARID1A: OR 4.39, p = 4.56E–17; TP53: OR 2.67, p = 3.01E–17; ATR: OR 7.55, p = 8.0E–4; ATM: OR 3.69, p = 5.95E–07; BRCA2: OR 4.10, p = 5.42E–05) and PC (TP53: OR 3.81, p = 4.07E–06). Here, TP53 is linked to colorectal carcinoma.