The incidence of TMB-high (defined as ≥10 mutations per megabase [mut/Mb]) and PD-L1-high (score cut-off = TPS 1 for CRC, OC and PC; CPS 10 for BC; and TPS 50 for NSCLC) tumours differed among cancer types. Here, CD274 is linked to pachyonychia congenita.