TP53 and pachyonychia congenita: SV mutations were the most common GA type across tumour types and genes (Fig. 1); specifically, SV mutations accounted for 47.1% of the TP53 GAs in BC, 69.7% in CRC, 60.3% in NSCLC, 73.5% in OC and 34.2% in PC (Fig. 1f).