Of note, the high median TMB tumour types, NSCLC and BC, were particularly enriched with GAs in ATM. It has been shown that ATM-deficient cells have higher levels of type I interferon-stimulated genes (ISGs) and that ATR inhibition of these cells further increases ISG levels, resulting in dendritic cell activation64. The gene discussed is ATM; the disease is non-small cell lung carcinoma.