As this analysis revealed that certain genes displayed particularly significant associations with TMB, we focused on genes with a log10(p value) of >20 and a log10(OR) of >0.5 and found significant associations between mutations in multiple mismatch repair genes and TMB in all tumour types (CRC: MLH1, MSH2, MSH6 and PMS2; NSCLC: MLH1 and MSH2; OC: MSH2 and MSH6; PC: MLH1, MSH2 and MSH6), except BC. The gene discussed is MSH6; the disease is breast cancer.