CHEK2 and pachyonychia congenita: In addition, germline mutations were primarily identified (Fig. 2a–e) in MUTYH (BC, 1.3%; CRC, 1.5%; NSCLC, 1.3%; OC, 1.1%; PC, 1.2%) and CHEK2 (BC, 1.0%; CRC, 0.6%; NSCLC, 0.7%; OC, 0.6%; PC, 1.0%).