Meanwhile, the trend of caspase3 in medulloblastoma cell lines DAOY after modulation of VASH2 was consistent with that of Bcl2, a proto-oncogene that inhibits apoptosis, and earlier studies have shown that Bcl2 is a downstream target gene of the SHH signaling pathway, and the expression level of SHH in medulloblastoma cell-lines DAOY was significantly increased by knockdown of VASH2, while the expression level of Bcl2 in SHH medulloblastoma cell-lines DAOY was significantly inhibited by knockdown of VASH2. The gene discussed is SHH; the disease is medulloblastoma.