The results of one study showed that VASH2 could inhibit apoptosis in liver tumor cells by down-regulating p53, and earlier results showed that the p53 gene was highly expressed in SHH medulloblastoma cell lines DAOY, thus suggesting that VASH2 could also mediate apoptosis in SHH medulloblastoma cell-lines DAOY through the p53 gene48. This evidence concerns the gene TP53 and medulloblastoma.