EGFR and non-small cell lung carcinoma: This study identifies a key role of WDR4/PTPN23 axis in NSCLC progression by suppressing lysosomal degradation of EGFR and c-MET and suggests a previously unappreciated strategy for treating EGFR TKI-resistant NSCLC by reactivating the degradation of EGFR mutant and c-MET.