First, dynamin 1, a neuron-enriched dynamin isoform, is activated in NSCLC through the Akt/GSK3β signaling pathway and this activation alters clathrin-mediated endocytosis by increasing the initiation of clathrin-coated pits (CCP) assembly but impairing CCP maturation, resulting in an increased cargo recycling [51]. Here, AKT1 is linked to non-small cell lung carcinoma.