Given the inverse relevance of Trim26 expression with severity of NASH in mice models with Trim26 loss-of-function experiments based on Rosa26 conditional and/or inducible transgenesis (hereunder named as Rosa26Trim26) (P < 0.0001 by 2 tailed t test; Supplementary Fig. 10a, b). This evidence concerns the gene TRIM26 and metabolic dysfunction-associated steatohepatitis.