Of note, to better study the protective function of Trim26 in the NASH in vivo model, the ex vivo gene therapy strategy of lentivirus-loaded full-length Trim26 sequences (LV-Trim26) or shRNA targeting Trim26 (LV-shTrim26) was used to further explore the role of Trim26 in the alleviation of steatohepatitis (Supplementary Fig. 6a–c). Here, TRIM26 is linked to metabolic dysfunction-associated steatohepatitis.