Besides, Trim26 ablation did slightly elevate Cebpd-Hif1a signalling and its corresponding downstream pathways, including Cebpd, Hif1a, Nos2, p-p38, and p-p65 protein, in HFHC- and WTDF-induced fatty liver and NASH serum-treated AdTRIM26- or AdshTRIM26-transfected L02 cells (Fig. 6a–d). Here, NOS2 is linked to metabolic dysfunction-associated steatohepatitis.