Moreover, we also assessed the performance in distinguishing IDH-mutant diffuse astrocytoma with IDH-mutant 1p/19q-codeleted oligodendroglioma (task 7), achieving subgroup AUCs ranging from 0.957 to 0.994 on all cohorts, as shown in Supplementary Fig. 9i–l and Table 1. This evidence concerns the gene IDH1 and diffuse astrocytoma.