C9orf72-SMCR8-containning complex were reported to act as the effector of Rab1 to affect the ULK1 complex trafficking to phagophore to initiate autophagy, partially explained why there is reduced basal autophagy level and p62 accumulation in ALS/FTD patient-derived iNeurons48,68. This evidence concerns the gene SMCR8 and amyotrophic lateral sclerosis.