Finally, the cytotoxic T‐cell marker CD8, important in promoting antitumor immune responses, inhibiting metastasis, and correlated with improved prognosis in BC (Joseph et al., 2021; Mahmoud et al., 2011), was significantly increased with perioperative emodin compared to PBS in wounded mice (Figure 5d; p = 0.0051). Here, CD8A is linked to breast cancer.