CD274 and neoplasm: A recent example of such a bifunctional ADC wasa small molecule immunomodulator attached to an anti-PD-L1 antibodyvia a cleavable disulfide linker, dubbed an immune modulating ADC(IM-ADC).396 The released payload was foundto exert its antitumor effect by inducing CD8+ and CD4+T cytotoxic lymphocyte infiltration.396 In addition, the payload increased PD-L1 expression, especiallyin tumor cells, thereby increasing the effectiveness of subsequentrounds of treatment with the same ADC.