TNFRSF8 and neoplasm: The presence of TAMs has been linked to the antitumorefficacy of the anti-CD-30 antibodies, SGN-30401 and SGN-40.402 TAMs have beenshown to enhance the uptake of a nontargeted ADC and the release ofits payload, leading to an enhanced bystander effect403 which enhances its toxicity to tumor cells with low orvariable antigen expression.