The AHD package of care includes: rapid initiation of ART (within 7 days) in the absence of contraindications, screening for active TB disease with TB treatment or TB Preventive Treatment (TPT) as indicated, cotrimoxazole prophylaxis, cryptococcal antigen screening (CrAg) for those with CD4 cell count <100 cells/mm3 (with additional consideration for CD4 <200 cells/mm3), treatment for cryptococcal meningitis (CM) or preemptive fluconazole therapy for those with cryptococcal infection without CM, and intensive follow-up. The gene discussed is CD4; the disease is cutaneous mastocytosis.