However, the histology data demonstrated increased collagen accumulation in the lung of STZ-induced AAT KO mice compared to STZ mice and AAT KO control mice, suggesting that 3 months after the onset of hyperglycemia was insufficient to induce changes in the extracellular matrix (ECM) in wildtype mice but AAT deficiency accelerated this histological change, which is observed only at 6 months in STZ mice. The gene discussed is SERPINA1; the disease is Hyperglycemia.