By 6 months after the onset of hyperglycemia, STZ mice showed visible accumulation of collagen in the upper (3.5-fold; p = 0.001) and lower lobes (4.3-fold; p < 0.0001) of the lung, along with a significant increase in mRNA expression of Acta2 and Ccn2 (Fig 2B). Here, ACTA2 is linked to Hyperglycemia.