MAPK8 and ocular hypertension: We also revealed that ocular hypertension induced by anterior chamber injections of microbeads led to the activation of MAPK signaling pathway as shown by increased levels of p-ERK, p-p38, and p-JNK, while intraocular injection of cGlra2 shRNA but not scrambled shRNA led to the inactivation of MAPK signaling pathway (Supplementary Figure 2C).