IL6 and pancreatic ductal adenocarcinoma: Upregulation of circCUL2 expression induces an activated CAF phenotype, which functions as a ceRNA and modulates the miR-203a-3p/MyD88/NF-κB/IL6 axis, then promotes the progression of pancreatic ductal adenocarcinoma (PDAC) by secreting IL-6 [65].