For instance, in ovarian cancer, exosome-derived circATP2B4 can be delivered to infiltrating macrophages and induce M2-type polarization through modulation of the miR-532-3p/SREBF1/PI3Kα/AKT axis, leading to immunosuppression and ovarian cancer metastasis [105]. This evidence concerns the gene AKT1 and ovarian carcinoma.