Additionally, circ-Erbin acts as a sponge for miR-125a-5p and miR-138-5p, targeting eukaryotic translation initiation factor 4E-binding protein 1 (4EBP-1), accelerating cap-independent protein translation of HIF-1α in CRC cells, and promoting angiogenesis [80]. This evidence concerns the gene EIF4EBP1 and colorectal carcinoma.