CCND1 and cholangiocarcinoma: As a result, MYC and CCND1 are upregulated leading to CRC progression and angiogenesis [30].Circ-CCAC1 derived from extracellular vesicles disrupts endothelial barrier integrity when translocated onto endothelial monolayers thereby inducing angiogenesis in cholangiocarcinoma (CCA) [31].