Furthermore, TAMs-derived exosomes transfer hsa_circ_0001610 to endometrial cancer cells and enhance cyclin B1 expression by adsorbing miR-139-5p, thereby reducing the radiosensitivity of endometrial cancer cells [113]. Additionally, the exosomes circZNF451 inhibit anti-PD1 therapy in lung adenocarcinoma by polarizing macrophages in complex with TRIM56 and FXR1 [114]. The gene discussed is TRIM56; the disease is endometrial cancer.