Additionally, the circ-FNDC3B derived from the FNDC3B gene plays a crucial role in various tumors such as gastric cancer, esophageal cancer, and colorectal cancer [45–47], it promotes tumor epithelial-mesenchymal transition (EMT), invasion, and metastasis by regulating E-cadherin and CD44. This evidence concerns the gene FNDC3B and esophageal cancer.