In osteosarcoma, the YY1 transcription factor induces upregulation of circFIRRE and partially increases mRNA and protein levels of LUZP1 by adsorbing miR-486-3p and miR-1225-5p, promoting tumor cell growth and angiogenesis, thereby driving primary osteosarcoma progression and lung metastasis [32]. The gene discussed is YY1; the disease is osteosarcoma.