Another important takeaway from GWAS is the fact that numerous common polymorphisms associated with polygenic obesity in ethnically diverse population have been found in genes like PCSK1 [40–42], MC4R [43••] and POMC, known to carry rare loss of function variants leading to non-syndromic monogenic obesity. The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.