identified IL-1β as the HS-5 bone marrow stromal cell-secreted paracrine factor responsible for AR mRNA downregulation in C4-2 PCa cell line (LNCaP derived subcutaneous xenograft tumor of castrated mouse) through upregulation of p62, a multifunctional adaptor needed for NF-κB pathway activation [135]. Here, NFKB1 is linked to neoplasm.