In this sense, it has been postulated that AIM2 could be exerting this tumor suppressor role through the regulation of PTEN on the ATK pathway, and by the activation of the proto-oncogene c-Myc, in a very specific context where gut microbiota and the AIM2 dsDNA sensing capacity could be crucial, although mechanistic details are lacking [92]. Here, AIM2 is linked to neoplasm.