NLRP3 and obesity due to melanocortin 4 receptor deficiency: In addition, the presence of NLRP3 inflammasome components in a mouse model of diet-induced obesity was higher in AT macrophages (ATMs) and SVF than in mature adipocytes of epididymal fat tissue, which suggested a theoretical model based on positive feed-forward loops among adipocytes, macrophages, and T cells [166].