Recently, the analysis of the whole plasma miRNome from PCa patients pointed out miR-107 as the best discriminatory miRNA between PCa and control patients, showing even better discrimination capacity when only patients with obesity were considered [33]; likewise, miR-4454 levels are highly altered and associated with metabolic disorders such as obesity and insulin metabolism in PCa [217]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.