TXNIP and type 2 diabetes mellitus: Furthermore, in a T2D-induced mouse model, fenofibrate (a PPARα agonist) was able to inhibit NLRP3 inflammasome and the subsequent IL1-β production through a ROS-dependent mechanism that implies thioredoxin-interacting protein (TXNIP), improving the angiogenic epithelial precursor cells ability [175].