In fact, NF-κB pathway activation itself seems to be sufficient to allow prostate and PCa to grow in an androgen-independent manner through AR activity regulation, confer protection against apoptosis, and participate in the induction of metastatic phenotype, thus being considered the most important effector of pro-inflammatory processes involved in PCa pathogenesis by various authors [138, 141, 142]. Here, NFKB1 is linked to posterior cortical atrophy.