GSTO1 and cardiovascular disorder: On the other hand, in the study of gene-environment interactions, it was shown that SNP in the GSTO1 gene, which was related to arsenic metabolism, exhibited significant interactions with cardiovascular disease, coronary heart disease or stroke [99]. These findings indicate that there might be a considerable number of unrecognized processes and mechanisms involved in the genes encoding the GST isoenzymes, which when disrupted, could contribute to cardiovascular diseases.