Mutations in SCN1A are associated with different neurological diseases, from the relatively mild genetic epilepsy with febrile seizures plus (GEFS+) to the severe myoclonic epilepsy in infancy (SMEI), also known as Dravet syndrome (DS), OMIM 607208 [5]. Here, SCN1A is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.