In addition, our study showed that circulating osteoglycin levels in patients with T2D increased stepwise from the lowest quartile to the highest quartile of TG/HDL-c index, with significant differences between quartile 1 and quartile 4 (P = 0.039; Fig. 3), suggesting that osteoglycin is highly related to this index. The gene discussed is OGN; the disease is type 2 diabetes mellitus.