Importantly, hiPSC-derived cortical neurons expressing acetylation-mimic TDP-43K145Q showed impaired splicing of putative FTLD-ALS spectrum disease biomarkers UNC13A and STMN2 (Brown et al., 2022; Prudencio et al., 2020; Melamed et al., 2019; Ma et al., 2022). Here, STMN2 is linked to amyotrophic lateral sclerosis.