TARDBP and Cognitive impairment: TDP-43KQ/KQ mouse neocortex harbored insoluble phosphorylated TDP-43 at the disease-associated Ser409/410 locus (Neumann et al., 2009) (p409/410) at 12 months of age, which was even more prominent at 18 months (Figure 6A, C), a timepoint at which TDP-43KQ/KQ mice showed behavioral and cognitive defects (Figure 4).