Importantly, all of these synaptic regulators (Nos1, Lrp8, Argef2, Sema5b) and other significantly altered splice variants (e.g., Adipor2, Mapk14, Smarca4, Sort1, Mapt) have been linked to AD and other neurodegenerative diseases (Park et al., 2016; Hinrich et al., 2016; Calabrese et al., 2007; Sun et al., 2020; Zhu et al., 2001; Alam and Scheper, 2016; Waragai et al., 2017; Shi et al., 2021; Guix et al., 2005; Chong et al., 2018; Seto et al., 2022). The gene discussed is LRP8; the disease is neurodegenerative disease.