It is also notable that TDP-43 pathology is abundant in other sporadic neurodegenerative diseases including Alzheimer disease (AD) (Meneses et al., 2021; Tomé et al., 2020), Limbic-Predominant Age-related TDP-43 Encephalopathy (LATE) (Besser et al., 2020; Nelson et al., 2019), and Parkinson’s disease (PD) (Poulopoulos et al., 2012; Nakashima-Yasuda et al., 2007). Here, TARDBP is linked to Alzheimer disease.