RBFOX3 and proteostasis deficiencies: In addition to searching for aggregate pathology, we also evaluated TDP-43 abundance, as measured by fluorescence intensity, in NeuN-positive neurons, as TDP-43 expression is altered in FTLD-TDP and other TDP-43 proteinopathies (Budini and Buratti, 2011; Mishra et al., 2007; Gitcho et al., 2009; Chen-Plotkin et al., 2008), and visualized the single-cell resolution data using SuperPlots (Lord et al., 2020).