SHOX2 and cancer: These DMRs were enriched for regulatory regions of well-known cancer-related gene families such as PAX family genes, TBX family genes, FOX family genes, and HOX family genes, and some have previously been reported as biomarkers for non-invasive cancer diagnosis, such as SEPT9 and SHOX2 (Ilse et al., 2014; Warren et al., 2011).