As a member of the GCN5‐related NAT (GNAT) family of histone acetyltransferases, NAT10 serves as an enzymatic catalyst for ac4C modification on rRNAs, tRNAs, and mRNAs.[16] Regarding its involvement in various cancers, NAT10 has been implicated in the pathogenesis of hepatocellular carcinoma,[17] bladder cancer,[18] and acute myeloid leukemia.[19] Recently, Zhang et al. This evidence concerns the gene NAT10 and acute myeloid leukemia.