TGM2 and neuropathy: Gluten sensitivity is serologically defined by the presence of antigliadin antibodies, anti-transglutaminase (TG2/TG6) antibodies, and/or anti-endomysial antibodies (EMA). In a study of 28,232 patients with celiac disease and 139,473 age- and sex-matched controls, it was determined that the presence of celiac disease could be associated with a significant risk for subsequent neuropathy; in fact, those with celiac disease were 2.5 times more likely to develop neuropathy than those without the celiac disease [41].